Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5215552

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC6 (unknown origin) using BML-KI104 as substrate preincubated for 3 hrs followed by substrate addition measured after 60 mins by modified FLUOR DE LYS assay
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 6 (CHEMBL1865) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Yu W, Liu J, Clausen D, Yu Y, Duffy JL, Wang M, Xu S, Deng L, Suzuki T, Chung CC, Myers RW, Klein DJ, Fells JI, Holloway MK, Wu J, Wu G, Howell BJ, Barnard RJO, Kozlowski J.
J Med Chem (2021) 64 : 4709 -4729
PubMed 33797924 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 6.02 7.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4862556 — — 1 7.13
CHEMBL5219811 — — 1 7.08
CHEMBL5220715 — — 1 7.08
CHEMBL5218487 — — 1 6.80
CHEMBL5218586 — — 1 6.70
CHEMBL5218693 — — 1 6.66
CHEMBL5220120 — — 1 6.58
CHEMBL5219294 — — 1 6.57
CHEMBL5219490 — — 1 6.52
CHEMBL5219875 — — 1 6.52
CHEMBL5220576 — — 1 6.51
CHEMBL5220454 — — 1 6.51
CHEMBL5219825 — — 1 6.51
CHEMBL5219409 — — 1 6.50
CHEMBL5220926 — — 1 6.46
CHEMBL5218749 — — 1 6.35
CHEMBL5220278 — — 1 6.34
CHEMBL5218854 — — 1 6.34
CHEMBL5220844 — — 1 6.26
CHEMBL5221097 — — 1 6.25
CHEMBL5220360 — — 1 6.21
CHEMBL5219590 — — 1 6.18
CHEMBL5218535 — — 1 6.16
CHEMBL5219039 — — 1 6.12
CHEMBL5218767 — — 1 6.01
CHEMBL5218553 — — 1 6.00
CHEMBL5220815 — — 1 5.92
CHEMBL5218556 — — 1 5.82
CHEMBL4745088 — — 1 5.82
CHEMBL5220616 — — 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4862556 — IC50 = 74.0 nM 7.13
CHEMBL5219811 — IC50 = 84.0 nM 7.08
CHEMBL5220715 — IC50 = 83.0 nM 7.08
CHEMBL5218487 — IC50 = 160.0 nM 6.80
CHEMBL5218586 — IC50 = 200.0 nM 6.70
CHEMBL5218693 — IC50 = 220.0 nM 6.66
CHEMBL5220120 — IC50 = 260.0 nM 6.58
CHEMBL5219294 — IC50 = 270.0 nM 6.57
CHEMBL5219490 — IC50 = 300.0 nM 6.52
CHEMBL5219875 — IC50 = 300.0 nM 6.52
CHEMBL5220576 — IC50 = 310.0 nM 6.51
CHEMBL5220454 — IC50 = 310.0 nM 6.51
CHEMBL5219825 — IC50 = 310.0 nM 6.51
CHEMBL5219409 — IC50 = 320.0 nM 6.50
CHEMBL5220926 — IC50 = 350.0 nM 6.46
CHEMBL5218749 — IC50 = 450.0 nM 6.35
CHEMBL5220278 — IC50 = 460.0 nM 6.34
CHEMBL5218854 — IC50 = 460.0 nM 6.34
CHEMBL5220844 — IC50 = 550.0 nM 6.26
CHEMBL5221097 — IC50 = 560.0 nM 6.25
CHEMBL5220360 — IC50 = 620.0 nM 6.21
CHEMBL5219590 — IC50 = 660.0 nM 6.18
CHEMBL5218535 — IC50 = 690.0 nM 6.16
CHEMBL5219039 — IC50 = 750.0 nM 6.12
CHEMBL5218767 — IC50 = 970.0 nM 6.01
CHEMBL5218553 — IC50 = 990.0 nM 6.00
CHEMBL5220815 — IC50 = 1200.0 nM 5.92
CHEMBL5218556 — IC50 = 1500.0 nM 5.82
CHEMBL4745088 — IC50 = 1500.0 nM 5.82
CHEMBL5220616 — IC50 = 1500.0 nM 5.82
CHEMBL5219241 — IC50 = 1800.0 nM 5.75
CHEMBL4856631 — IC50 = 2000.0 nM 5.70
CHEMBL5219006 — IC50 = 2900.0 nM 5.54
CHEMBL5219118 — IC50 = 3100.0 nM 5.51
CHEMBL5219634 — IC50 = 4200.0 nM 5.38
CHEMBL5219978 — IC50 = 4200.0 nM 5.38
CHEMBL5218537 — IC50 = 4300.0 nM 5.37
CHEMBL5219739 — IC50 = 4400.0 nM 5.36
CHEMBL5219969 — IC50 = 5600.0 nM 5.25
CHEMBL5221068 — IC50 = 7600.0 nM 5.12
CHEMBL5218918 — IC50 = 7800.0 nM 5.11
CHEMBL5218926 — IC50 = 7700.0 nM 5.11
CHEMBL5219422 — IC50 = 7800.0 nM 5.11
CHEMBL5219074 — IC50 = 10000.0 nM 5.00
CHEMBL5219338 — IC50 = 45000.0 nM 4.35
CHEMBL5219115 — IC50 > 900.0 nM -
CHEMBL5220254 — IC50 > 900.0 nM -
CHEMBL5218651 — IC50 > 900.0 nM -
CHEMBL5220233 — IC50 > 900.0 nM -
CHEMBL5219359 — IC50 > 150.0 nM -