Assay Detail
Functional
CHEMBL5215554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of HIV latency reactivation in Jurkat 2C4 cells assessed as reactivation of quiescent HIV provirus incubated for 15 mins in presence of 0.1 % normal human serum by Steady-Glo Luciferase Assay System
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 54 | 7.04 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220926 | — | — | 1 | 8.22 |
| CHEMBL5219825 | — | — | 1 | 8.15 |
| CHEMBL5219294 | — | — | 1 | 8.10 |
| CHEMBL5219875 | — | — | 1 | 8.00 |
| CHEMBL5220360 | — | — | 1 | 7.96 |
| CHEMBL5219409 | — | — | 1 | 7.77 |
| CHEMBL5219739 | — | — | 1 | 7.72 |
| CHEMBL5218854 | — | — | 1 | 7.62 |
| CHEMBL5218553 | — | — | 1 | 7.62 |
| CHEMBL5218693 | — | — | 1 | 7.58 |
| CHEMBL5218537 | — | — | 1 | 7.58 |
| CHEMBL5218556 | — | — | 1 | 7.57 |
| CHEMBL5220254 | — | — | 1 | 7.52 |
| CHEMBL5220233 | — | — | 1 | 7.50 |
| CHEMBL5219115 | — | — | 1 | 7.47 |
| CHEMBL5218651 | — | — | 1 | 7.46 |
| CHEMBL5218586 | — | — | 1 | 7.43 |
| CHEMBL5220278 | — | — | 1 | 7.41 |
| CHEMBL5219634 | — | — | 1 | 7.38 |
| CHEMBL5219422 | — | — | 1 | 7.30 |
| CHEMBL5218926 | — | — | 1 | 7.29 |
| CHEMBL5219006 | — | — | 1 | 7.22 |
| CHEMBL5219490 | — | — | 1 | 7.21 |
| CHEMBL5218918 | — | — | 1 | 7.21 |
| CHEMBL5220616 | — | — | 1 | 7.19 |
| CHEMBL5218767 | — | — | 1 | 7.07 |
| CHEMBL5220715 | — | — | 1 | 7.04 |
| CHEMBL5219039 | — | — | 1 | 7.03 |
| CHEMBL5219359 | — | — | 1 | 7.01 |
| CHEMBL4856631 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220926 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5219825 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5219294 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5219875 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5220360 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5219409 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5219739 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5218854 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5218553 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5218693 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5218537 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5218556 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5220254 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5220233 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5219115 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5218651 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5218586 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5220278 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5219634 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5219422 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5218926 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5219006 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5219490 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5218918 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5220616 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5218767 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5220715 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5219039 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5219359 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4856631 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4862556 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5218535 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5220969 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5220720 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5220454 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5220844 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5219969 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5220408 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5219118 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5219338 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5219978 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5220815 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5221068 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4745088 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5218980 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5218487 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5220120 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5220576 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5219811 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5221097 | — | EC50 | = | 970.0 | nM | 6.01 |