Assay Detail
Binding
CHEMBL5215684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FIH (unknown origin) by solid-phase extraction coupled to MS based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxia-inducible factor 1-alpha inhibitor (CHEMBL5909) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.47 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544988 | DAPRODUSTAT | 4.0 | 1 | 4.68 |
| CHEMBL3646221 | VADADUSTAT | 4.0 | 1 | 4.54 |
| CHEMBL3646118 | MOLIDUSTAT | 2.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544988 | DAPRODUSTAT | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3646221 | VADADUSTAT | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3646118 | MOLIDUSTAT | IC50 | = | 66000.0 | nM | 4.18 |