Assay Detail
Binding
CHEMBL5215722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TDO (19 to 388 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysis
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.65 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219865 | — | — | 1 | 7.40 |
| CHEMBL5220396 | — | — | 1 | 7.05 |
| CHEMBL5220677 | — | — | 1 | 6.92 |
| CHEMBL5218595 | — | — | 1 | 6.89 |
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 1 | 6.82 |
| CHEMBL5220436 | — | — | 1 | 6.72 |
| CHEMBL5218978 | — | — | 1 | 6.66 |
| CHEMBL5219702 | — | — | 1 | 6.48 |
| CHEMBL5219595 | — | — | 1 | 6.44 |
| CHEMBL5219170 | — | — | 1 | 6.40 |
| CHEMBL5220129 | — | — | 1 | 6.39 |
| CHEMBL5218511 | — | — | 1 | 6.35 |
| CHEMBL5218714 | — | — | 1 | 6.07 |
| CHEMBL5219723 | — | — | 1 | 6.04 |
| CHEMBL5220376 | — | — | 1 | 5.87 |
| CHEMBL5219838 | — | — | 1 | 5.77 |
| CHEMBL5220520 | — | — | 1 | 5.75 |
| CHEMBL3972619 | — | — | 1 | 5.73 |
| CHEMBL5218741 | — | — | 1 | 5.69 |
| CHEMBL5220402 | — | — | 1 | 5.69 |
| CHEMBL5219298 | — | — | 1 | 5.51 |
| CHEMBL5220937 | — | — | 1 | 5.47 |
| CHEMBL5220477 | — | — | 1 | 5.38 |
| CHEMBL5219328 | — | — | 1 | 5.22 |
| CHEMBL5221102 | — | — | 1 | 5.13 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 5.11 |
| CHEMBL5220441 | — | — | 1 | 4.98 |
| CHEMBL5221020 | — | — | 1 | 4.95 |
| CHEMBL5219631 | — | — | 1 | 4.90 |
| CHEMBL5218747 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219865 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5220396 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5220677 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5218595 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3989951 | NAVOXIMOD | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5220436 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5218978 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5219702 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5219595 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5219170 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5220129 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5218511 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5218714 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5219723 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5220376 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5219838 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5220520 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3972619 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5218741 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5220402 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5219298 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL5220937 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL5220477 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL5219328 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL5221102 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL5220441 | — | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL5221020 | — | IC50 | = | 11240.0 | nM | 4.95 |
| CHEMBL5219631 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL5218747 | — | IC50 | = | 12860.0 | nM | 4.89 |
| CHEMBL5218603 | — | IC50 | = | 27020.0 | nM | 4.57 |
| CHEMBL5220840 | — | IC50 | = | 33240.0 | nM | 4.48 |
| CHEMBL5219266 | — | IC50 | = | 39160.0 | nM | 4.41 |
| CHEMBL5218825 | — | IC50 | = | 44870.0 | nM | 4.35 |
| CHEMBL5219108 | — | IC50 | = | 58410.0 | nM | 4.23 |
| CHEMBL5218765 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL5219140 | — | IC50 | = | 84190.0 | nM | 4.08 |
| CHEMBL5220800 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5220341 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5218526 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5218529 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5218640 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5218896 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5219717 | — | IC50 | = | 147700.0 | nM | - |