Assay Detail
Binding
CHEMBL5215977
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Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constant
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical update on the potential for serotonin 5-HT<sub>6</sub> and 5-HT<sub>7</sub> receptor agents in the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.98 | 9.00 |
| K | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218527 | — | — | 1 | 9.00 |
| CHEMBL4205783 | JNJ-18038683 FREE BASE | 2.0 | 1 | 8.52 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 8.10 |
| CHEMBL5219333 | — | — | 1 | 7.47 |
| CHEMBL5219968 | — | — | 1 | 6.81 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | - |
| CHEMBL5219924 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218527 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4205783 | JNJ-18038683 FREE BASE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL589390 | LATREPIRDINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5219333 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL5219968 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL26 | SULPIRIDE | Ki | > | 3000.0 | nM | - |
| CHEMBL5219924 | — | K | = | 0.5 | nM | - |