Compound Detail
CHEMBL4205783
JNJ-18038683 FREE BASE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4205783 |
| Name | JNJ-18038683 FREE BASE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UKJPMZGILXATGT-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
337.9
MW (Da)
3.94
ALogP
3
HBA
1
HBD
29.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 6 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 8.52 | 8.52 | 3.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 8.22 | 7.6367 | 6.0 | 3 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 8.19 | 8.19 | 6.5 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4651402 | Vero C1008 | 2 |
| 29767995 | 10.1021/acs.jmedchem.7b01898 | 5-hydroxytryptamine receptor 7 | 1 |
| 31581003 | 10.1016/j.ejmech.2019.111705 | 5-hydroxytryptamine receptor 1A | 1 |
| 31581003 | 10.1016/j.ejmech.2019.111705 | 5-hydroxytryptamine receptor 7 | 1 |
| 33171218 | 10.1016/j.bmcl.2020.127669 | 5-hydroxytryptamine receptor 2A | 1 |
| 33171218 | 10.1016/j.bmcl.2020.127669 | 5-hydroxytryptamine receptor 7 | 1 |
| 34311086 | 10.1016/j.bmcl.2021.128275 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine