Assay Detail
Binding
CHEMBL4343397
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Antagonist activity at 5-HT1A receptor (unknown origin)
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of serotonin 5-HT<sub>7</sub> receptors ligands: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.58 | 8.19 |
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205783 | JNJ-18038683 FREE BASE | 2.0 | 1 | 8.19 |
| CHEMBL161765 | — | — | 1 | 7.80 |
| CHEMBL2164327 | — | — | 1 | 7.05 |
| CHEMBL3302600 | — | — | 1 | 6.92 |
| CHEMBL4533865 | — | — | 1 | 6.89 |
| CHEMBL69257 | — | — | 1 | 6.77 |
| CHEMBL427518 | — | — | 1 | 6.57 |
| CHEMBL348890 | — | — | 1 | 6.50 |
| CHEMBL2164336 | — | — | 1 | 6.32 |
| CHEMBL4582321 | — | — | 1 | 6.30 |
| CHEMBL4521657 | — | — | 1 | 6.25 |
| CHEMBL3139441 | — | — | 1 | 6.16 |
| CHEMBL4205349 | — | — | 1 | 6.16 |
| CHEMBL12624 | SB-258741 | — | 1 | 6.00 |
| CHEMBL409662 | — | — | 1 | 5.79 |
| CHEMBL232791 | — | — | 1 | 5.32 |
| CHEMBL282199 | — | — | 1 | - |
| CHEMBL12264 | SB-258719 | — | 1 | - |
| CHEMBL182797 | — | — | 1 | - |
| CHEMBL182322 | — | — | 1 | - |
| CHEMBL3321794 | — | — | 1 | - |
| CHEMBL4216782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205783 | JNJ-18038683 FREE BASE | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL161765 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2164327 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL3302600 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL4533865 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL69257 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL427518 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL348890 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL2164336 | — | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL4582321 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4521657 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL3139441 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL4205349 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL12624 | SB-258741 | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL409662 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL232791 | — | Ki | = | 4826.0 | nM | 5.32 |
| CHEMBL282199 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL12264 | SB-258719 | Ki | > | 3000.0 | nM | - |
| CHEMBL182797 | — | Ki | > | 100.0 | nM | - |
| CHEMBL182322 | — | Ki | > | 100.0 | nM | - |
| CHEMBL3321794 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4216782 | — | Ki | > | 10000.0 | nM | - |