Compound Detail
CHEMBL182322
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL182322 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UNUSDSJWMRJMCT-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
386.4
MW (Da)
3.40
ALogP
7
HBA
3
HBD
98.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 8.7 | 8.5 | 2.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 2.0 | nM | 8.7 | Antagonist activity at 5-HT7 receptor (unknown origin) | 31581003 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 5.0 | nM | 8.3 | Binding affinity against 5-Hydroxy tryptamine 7 receptor | 15261279 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15261279 | 10.1016/j.bmcl.2004.06.008 | 5-hydroxytryptamine receptor 7 | 1 |
| 31581003 | 10.1016/j.ejmech.2019.111705 | 5-hydroxytryptamine receptor 7 | 1 |
| 31581003 | 10.1016/j.ejmech.2019.111705 | 5-hydroxytryptamine receptor 1A | 1 |
Data from ChEMBL 36 via Core Engine