Assay Detail
Binding
CHEMBL828254
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Binding affinity against 5-Hydroxy tryptamine 7 receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminotriazine 5-HT7 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413049 | — | — | 1 | 8.70 |
| CHEMBL182937 | — | — | 1 | 8.70 |
| CHEMBL180086 | — | — | 1 | 8.70 |
| CHEMBL182174 | — | — | 1 | 8.52 |
| CHEMBL183862 | — | — | 1 | 8.52 |
| CHEMBL182322 | — | — | 1 | 8.30 |
| CHEMBL183462 | — | — | 1 | 8.10 |
| CHEMBL182797 | — | — | 1 | 8.10 |
| CHEMBL182418 | — | — | 1 | 8.05 |
| CHEMBL441312 | — | — | 1 | 8.00 |
| CHEMBL182840 | — | — | 1 | 7.64 |
| CHEMBL180946 | — | — | 1 | 7.44 |
| CHEMBL182805 | — | — | 1 | 7.27 |
| CHEMBL182121 | — | — | 1 | 7.22 |
| CHEMBL360374 | — | — | 1 | - |
| CHEMBL183347 | — | — | 1 | - |
| CHEMBL185560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413049 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL182937 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL180086 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL182174 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL183862 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL182322 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL183462 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL182797 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL182418 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL441312 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL182840 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL180946 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL182805 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL182121 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL360374 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL183347 | — | Ki | > | 41000.0 | nM | - |
| CHEMBL185560 | — | Ki | > | 1000.0 | nM | - |