Assay Detail
Binding
CHEMBL5216080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.69 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219079 | — | — | 1 | 9.05 |
| CHEMBL3219087 | — | — | 1 | 9.00 |
| CHEMBL3219102 | — | — | 1 | 8.52 |
| CHEMBL3219101 | — | — | 1 | 8.52 |
| CHEMBL3219100 | — | — | 1 | 8.52 |
| CHEMBL3219103 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219079 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL3219087 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3219102 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3219101 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3219100 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3219103 | — | Ki | = | 3.0 | nM | 8.52 |