Assay Detail
Binding
CHEMBL5216216
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Inhibition of mTORC2 in human A-431 cells assessed as phosphorylated AKT level incubated for 3 hrs by HTRF assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.52 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219718 | — | — | 1 | 9.00 |
| CHEMBL5218727 | — | — | 1 | 8.96 |
| CHEMBL5218916 | — | — | 1 | 8.92 |
| CHEMBL5219710 | — | — | 1 | 8.82 |
| CHEMBL5218988 | — | — | 1 | 8.66 |
| CHEMBL5220152 | — | — | 1 | 8.62 |
| CHEMBL5220536 | — | — | 1 | 8.57 |
| CHEMBL5220948 | — | — | 1 | 8.55 |
| CHEMBL5218590 | — | — | 1 | 8.23 |
| CHEMBL5220383 | — | — | 1 | 8.20 |
| CHEMBL5220500 | — | — | 1 | 7.94 |
| CHEMBL5221072 | — | — | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219718 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5218727 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5218916 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5219710 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5218988 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5220152 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5220536 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5220948 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5218590 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5220383 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5220500 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5221072 | — | IC50 | = | 16.3 | nM | 7.79 |