Assay Detail
Binding
CHEMBL5216263
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Inhibition of TDO in human BT-549 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BT-549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.04 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220107 | — | — | 1 | 8.47 |
| CHEMBL5218772 | — | — | 1 | 4.97 |
| CHEMBL5220064 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220107 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL5218772 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5220064 | — | IC50 | = | 20600.0 | nM | 4.69 |