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Assay Detail

CHEMBL5216358

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BChE (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.
Zhang H, Wang Y, Wang Y, Li X, Wang S, Wang Z.
Eur J Med Chem (2022) 240 : 114606 -114606
PubMed 35858523 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.64 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4089082 1 9.00
CHEMBL1081032 1 8.74
CHEMBL1080386 PHENETHYLCYMSERINE 1 8.22
CHEMBL204895 1 8.22
CHEMBL94 PHYSOSTIGMINE 3.0 1 7.80
CHEMBL178792 1 7.66
CHEMBL206642 1 7.57
CHEMBL5220673 1 7.35
CHEMBL129837 4-ISOPROPYLPHENSERINE 1 7.30
CHEMBL5220069 1 6.99
CHEMBL5084655 1 6.99
CHEMBL74926 PHENSERINE 1 5.81
CHEMBL426674 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4089082 IC50 = 1.0 nM 9.00
CHEMBL1081032 IC50 = 1.8 nM 8.74
CHEMBL1080386 PHENETHYLCYMSERINE IC50 = 6.0 nM 8.22
CHEMBL204895 IC50 = 6.0 nM 8.22
CHEMBL94 PHYSOSTIGMINE IC50 = 16.0 nM 7.80
CHEMBL178792 IC50 = 22.0 nM 7.66
CHEMBL206642 IC50 = 27.0 nM 7.57
CHEMBL5220673 IC50 = 44.5 nM 7.35
CHEMBL129837 4-ISOPROPYLPHENSERINE IC50 = 50.0 nM 7.30
CHEMBL5220069 IC50 = 102.0 nM 6.99
CHEMBL5084655 IC50 = 102.0 nM 6.99
CHEMBL74926 PHENSERINE IC50 = 1560.0 nM 5.81
CHEMBL426674 IC50 > 30000.0 nM -