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Assay Detail

CHEMBL5216754

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Functional
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Comparative analysis of p-terphenylquinone and seriniquinone derivatives as reactive oxygen species-modulating agents.
Nagao H, Ninomiya M, Sugiyama H, Itabashi A, Uno K, Tanaka K, Koketsu M.
Bioorg Med Chem Lett (2022) 76 : 128992 -128992
PubMed 36126897 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.79 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4437459 1 7.16
CHEMBL5219417 1 5.80
CHEMBL4438542 1 5.76
CHEMBL5218704 1 5.54
CHEMBL4593579 1 5.24
CHEMBL467203 BETULINAN A 1 5.23
CHEMBL480678 1 -
CHEMBL5218562 1 -
CHEMBL5218866 1 -
CHEMBL5219613 1 -
CHEMBL1977783 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4437459 IC50 = 70.0 nM 7.16
CHEMBL5219417 IC50 = 1570.0 nM 5.80
CHEMBL4438542 IC50 = 1730.0 nM 5.76
CHEMBL5218704 IC50 = 2910.0 nM 5.54
CHEMBL4593579 IC50 = 5710.0 nM 5.24
CHEMBL467203 BETULINAN A IC50 = 5910.0 nM 5.23
CHEMBL480678 IC50 > 25000.0 nM -
CHEMBL5218562 IC50 > 25000.0 nM -
CHEMBL5218866 IC50 > 25000.0 nM -
CHEMBL5219613 IC50 > 25000.0 nM -
CHEMBL1977783 IC50 > 25000.0 nM -