Assay Detail
Binding
CHEMBL5216850
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Inhibition of recombinant Mycobacterium tuberculosis H37Rv MptpB using pNPP as substrate incubated for 10 mins and measured by spectrophotometric method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine-protein phosphatase PTPB (CHEMBL4540) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.89 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647367 | — | — | 1 | 8.19 |
| CHEMBL3769851 | — | — | 1 | 7.75 |
| CHEMBL2316902 | — | — | 1 | 7.42 |
| CHEMBL5218633 | — | — | 1 | 5.98 |
| CHEMBL5220804 | — | — | 1 | 5.93 |
| CHEMBL4214022 | — | — | 1 | 5.53 |
| CHEMBL5218779 | — | — | 1 | 5.44 |
| CHEMBL5219572 | — | — | 1 | 5.42 |
| CHEMBL5220330 | — | — | 1 | 5.42 |
| CHEMBL5220182 | — | — | 1 | 5.33 |
| CHEMBL5220490 | — | — | 1 | 5.27 |
| CHEMBL5220318 | — | — | 1 | 5.22 |
| CHEMBL5220166 | — | — | 1 | 4.85 |
| CHEMBL5220755 | — | — | 1 | 4.65 |
| CHEMBL5218985 | — | — | 1 | - |
| CHEMBL5220271 | — | — | 1 | - |
| CHEMBL5220193 | — | — | 1 | - |
| CHEMBL5221099 | — | — | 1 | - |
| CHEMBL5220555 | — | — | 1 | - |
| CHEMBL5219842 | — | — | 1 | - |
| CHEMBL5220261 | — | — | 1 | - |
| CHEMBL5219450 | — | — | 1 | - |
| CHEMBL5219262 | — | — | 1 | - |
| CHEMBL5220362 | — | — | 1 | - |
| CHEMBL5220180 | — | — | 1 | - |
| CHEMBL5219788 | — | — | 1 | - |
| CHEMBL5218569 | — | — | 1 | - |
| CHEMBL5221000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647367 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3769851 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2316902 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5218633 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5220804 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL4214022 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL5218779 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL5219572 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5220330 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5220182 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5220490 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL5220318 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL5220166 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL5220755 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL5218985 | — | IC50 | - | — | - | |
| CHEMBL5220271 | — | IC50 | - | — | - | |
| CHEMBL5220193 | — | IC50 | - | — | - | |
| CHEMBL5221099 | — | IC50 | - | — | - | |
| CHEMBL5220555 | — | IC50 | - | — | - | |
| CHEMBL5219842 | — | IC50 | - | — | - | |
| CHEMBL5220261 | — | IC50 | - | — | - | |
| CHEMBL5219450 | — | IC50 | - | — | - | |
| CHEMBL5219262 | — | IC50 | - | — | - | |
| CHEMBL5220362 | — | IC50 | - | — | - | |
| CHEMBL5220180 | — | IC50 | - | — | - | |
| CHEMBL5219788 | — | IC50 | - | — | - | |
| CHEMBL5218569 | — | IC50 | - | — | - | |
| CHEMBL5221000 | — | IC50 | - | — | - |