Assay Detail
Binding
CHEMBL5216856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Mycobacterium tuberculosis H37Rv MptpA using pNPP as substrate incubated for 10 mins and measured by spectrophotometric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.88 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220804 | — | — | 1 | 5.05 |
| CHEMBL5219572 | — | — | 1 | 4.70 |
| CHEMBL5220330 | — | — | 1 | - |
| CHEMBL5220490 | — | — | 1 | - |
| CHEMBL5220182 | — | — | 1 | - |
| CHEMBL5220318 | — | — | 1 | - |
| CHEMBL5218779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220804 | — | IC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL5219572 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5220330 | — | IC50 | - | — | - | |
| CHEMBL5220490 | — | IC50 | - | — | - | |
| CHEMBL5220182 | — | IC50 | - | — | - | |
| CHEMBL5220318 | — | IC50 | - | — | - | |
| CHEMBL5218779 | — | IC50 | - | — | - |