Assay Detail
Binding
CHEMBL5217128
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Binding affinity to human Sirt3 (118 to 399 residues) assessed as dissociation constant using 625nM acetylated MnSOD peptide as substrate by microscale thermophoresis analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (CHEMBL4461) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel compounds as potent activators of Sirt3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16901 | HONOKIOL | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16901 | HONOKIOL | Kd | = | 2990.0 | nM | 5.52 |