Assay Detail
Binding
CHEMBL5217152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 at 10 uM using pNPP as substrate incubated for 10 mins by microplate reader based spectrophotometric analysis relative to control
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight phosphotyrosine protein phosphatase (CHEMBL4903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 25 | - | - |
| IC50 | 1 | 5.28 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794972 | — | — | 1 | 5.28 |
| CHEMBL5219045 | — | — | 1 | - |
| CHEMBL5221038 | — | — | 1 | - |
| CHEMBL5218818 | — | — | 1 | - |
| CHEMBL5220050 | — | — | 1 | - |
| CHEMBL5219097 | — | — | 1 | - |
| CHEMBL5220046 | — | — | 1 | - |
| CHEMBL5219738 | — | — | 1 | - |
| CHEMBL5220450 | — | — | 1 | - |
| CHEMBL5220012 | — | — | 1 | - |
| CHEMBL5221105 | — | — | 1 | - |
| CHEMBL5220336 | — | — | 1 | - |
| CHEMBL5219144 | — | — | 1 | - |
| CHEMBL5220897 | — | — | 1 | - |
| CHEMBL5220151 | — | — | 1 | - |
| CHEMBL5219412 | — | — | 1 | - |
| CHEMBL5220232 | — | — | 1 | - |
| CHEMBL5218812 | — | — | 1 | - |
| CHEMBL5219138 | — | — | 1 | - |
| CHEMBL5220479 | — | — | 1 | - |
| CHEMBL5219550 | — | — | 1 | - |
| CHEMBL5219481 | — | — | 1 | - |
| CHEMBL5219658 | — | — | 1 | - |
| CHEMBL5218705 | — | — | 1 | - |
| CHEMBL5219364 | — | — | 1 | - |
| CHEMBL5218991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794972 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL5219045 | — | Inhibition | - | % | - | |
| CHEMBL5221038 | — | Inhibition | - | % | - | |
| CHEMBL5218818 | — | Inhibition | - | % | - | |
| CHEMBL5220050 | — | Inhibition | - | % | - | |
| CHEMBL5219097 | — | Inhibition | - | % | - | |
| CHEMBL5220046 | — | Inhibition | - | % | - | |
| CHEMBL5219738 | — | Inhibition | - | % | - | |
| CHEMBL5220450 | — | Inhibition | - | % | - | |
| CHEMBL5220012 | — | Inhibition | - | % | - | |
| CHEMBL5221105 | — | Inhibition | - | % | - | |
| CHEMBL5220336 | — | Inhibition | - | % | - | |
| CHEMBL5219144 | — | Inhibition | - | % | - | |
| CHEMBL5220897 | — | Inhibition | - | % | - | |
| CHEMBL5220151 | — | Inhibition | - | % | - | |
| CHEMBL5219412 | — | Inhibition | - | % | - | |
| CHEMBL5220232 | — | Inhibition | - | % | - | |
| CHEMBL5218812 | — | Inhibition | - | % | - | |
| CHEMBL5219138 | — | Inhibition | - | % | - | |
| CHEMBL5220479 | — | Inhibition | - | % | - | |
| CHEMBL5219550 | — | Inhibition | - | % | - | |
| CHEMBL5219481 | — | Inhibition | - | % | - | |
| CHEMBL5219658 | — | Inhibition | - | % | - | |
| CHEMBL5218705 | — | Inhibition | - | % | - | |
| CHEMBL5219364 | — | Inhibition | - | % | - | |
| CHEMBL5218991 | — | Inhibition | - | % | - |