Assay Detail
Binding
CHEMBL5217153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 using pNPP as substrate incubated for 10 mins by microplate reader based spectrophotometric analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight phosphotyrosine protein phosphatase (CHEMBL4903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.00 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218807 | — | — | 1 | 8.40 |
| CHEMBL5219822 | — | — | 1 | 8.10 |
| CHEMBL5218783 | — | — | 1 | 7.31 |
| CHEMBL5220687 | — | — | 1 | 7.25 |
| CHEMBL5220615 | — | — | 1 | 6.92 |
| CHEMBL5220051 | — | — | 1 | 6.70 |
| CHEMBL5218478 | — | — | 1 | 6.52 |
| CHEMBL5219403 | — | — | 1 | 6.52 |
| CHEMBL5219065 | — | — | 1 | 6.40 |
| CHEMBL5218609 | — | — | 1 | 6.40 |
| CHEMBL5218798 | — | — | 1 | 6.22 |
| CHEMBL5218883 | — | — | 1 | 5.92 |
| CHEMBL5221084 | — | — | 1 | 5.82 |
| CHEMBL5220114 | — | — | 1 | 5.82 |
| CHEMBL5219085 | — | — | 1 | 5.82 |
| CHEMBL5219469 | — | — | 1 | 5.82 |
| CHEMBL5219423 | — | — | 1 | 5.77 |
| CHEMBL5219519 | — | — | 1 | 5.66 |
| CHEMBL5220487 | — | — | 1 | 5.47 |
| CHEMBL5219635 | — | — | 1 | 5.47 |
| CHEMBL5220131 | — | — | 1 | 5.36 |
| CHEMBL5219411 | — | — | 1 | 5.28 |
| CHEMBL5219998 | — | — | 1 | 5.27 |
| CHEMBL5219580 | — | — | 1 | 5.22 |
| CHEMBL5220369 | — | — | 1 | 5.22 |
| CHEMBL5220894 | — | — | 1 | 5.07 |
| CHEMBL5218748 | — | — | 1 | 4.94 |
| CHEMBL5219215 | — | — | 1 | 4.91 |
| CHEMBL5219416 | — | — | 1 | 4.52 |
| CHEMBL5218939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218807 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5219822 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5218783 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5220687 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5220615 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5220051 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5218478 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5219403 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5219065 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5218609 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5218798 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5218883 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5221084 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5220114 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5219085 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5219469 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5219423 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5219519 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5220487 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5219635 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5220131 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5219411 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5219998 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5219580 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5220369 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5220894 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL5218748 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5219215 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5219416 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5218939 | — | IC50 | > | 100000.0 | nM | - |