Assay Detail
Binding
CHEMBL5217245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.31 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297188 | MIRANSERTIB | 2.0 | 1 | 8.85 |
| CHEMBL5220876 | — | — | 1 | 7.07 |
| CHEMBL5221128 | — | — | 1 | 7.05 |
| CHEMBL5220918 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297188 | MIRANSERTIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5220876 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5221128 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5220918 | — | IC50 | = | 558.0 | nM | 6.25 |