Compound Detail
CHEMBL4297188
MIRANSERTIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4297188 |
| Name | MIRANSERTIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | HNFMVVHMKGFCMB-UHFFFAOYSA-N |
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
16
Publications
6
Known Names
5
Indications
1
Mechanisms
Molecular Properties
432.5
MW (Da)
5.07
ALogP
6
HBA
2
HBD
95.6
PSA (Ų)
0.41
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serine/threonine-protein kinase AKT inhibitor | INHIBITOR | Serine/threonine-protein kinase AKT | ✓ | ✓ |
Indications
Proteus Syndrome Endometrial Neoplasms Lymphoma Neoplasms Ovarian Neoplasms
Activity Summary
IC50 7 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 8.89 | 8.595 | 1.3 | 2 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 8.85 | 8.6 | 1.4 | 2 |
| Serine/threonine-protein kinase AKT CHEMBL2111353 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| RAC-gamma serine/threonine-protein kinase CHEMBL4816 | IC50 | 8.0 | 7.9 | 9.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 1.3 | nM | 8.89 | Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-A... | 36197750 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 1.4 | nM | 8.85 | Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-A... | 36197750 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 4.5 | nM | 8.35 | Inhibition of AKT2 (unknown origin) | 36503229 |
| Serine/threonine-protein kinase AKT | IC50 | = | 5.0 | nM | 8.3 | Inhibition of AKT (unknown origin) in presence of ATP | 35312319 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 5.0 | nM | 8.3 | Inhibition of AKT1 (unknown origin) | 36503229 |
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 9.9 | nM | 8.0 | Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-A... | 36197750 |
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 16.0 | nM | 7.8 | Inhibition of AKT3 (unknown origin) | 36503229 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | RAC-alpha serine/threonine-protein kinase | 4 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | SW-620 | 2 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | Proline-rich AKT1 substrate 1 | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 35312319 | 10.1021/acs.jmedchem.2c00073 | Serine/threonine-protein kinase AKT | 1 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | Unchecked | 1 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | RAC-beta serine/threonine-protein kinase | 1 |
| 36197750 | 10.1021/acs.jmedchem.2c01454 | RAC-gamma serine/threonine-protein kinase | 1 |
| 36503229 | 10.1021/acs.jmedchem.2c01070 | RAC-alpha serine/threonine-protein kinase | 1 |
| 36503229 | 10.1021/acs.jmedchem.2c01070 | RAC-beta serine/threonine-protein kinase | 1 |
| 36503229 | 10.1021/acs.jmedchem.2c01070 | RAC-gamma serine/threonine-protein kinase | 1 |
| - | 10.6019/EOS300108 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine