Assay Detail
Binding
CHEMBL5225408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.25 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | 1.0 | 1 | 9.26 |
| CHEMBL4795065 | Borussertib | — | 1 | 9.00 |
| CHEMBL4297188 | MIRANSERTIB | 2.0 | 1 | 8.30 |
| CHEMBL4635254 | — | — | 1 | 8.10 |
| CHEMBL5267341 | — | — | 1 | 7.42 |
| CHEMBL5282715 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4795065 | Borussertib | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4297188 | MIRANSERTIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4635254 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5267341 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5282715 | — | IC50 | = | 39.0 | nM | 7.41 |