Assay Detail
Binding
CHEMBL5225410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.96 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | 1.0 | 1 | 8.89 |
| CHEMBL4297188 | MIRANSERTIB | 2.0 | 1 | 7.80 |
| CHEMBL4635254 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4297188 | MIRANSERTIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4635254 | — | IC50 | = | 65.0 | nM | 7.19 |