Assay Detail
Binding
CHEMBL5225409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.15 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | 1.0 | 1 | 9.09 |
| CHEMBL4297188 | MIRANSERTIB | 2.0 | 1 | 8.35 |
| CHEMBL4635254 | — | — | 1 | 7.92 |
| CHEMBL4795065 | Borussertib | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802156 | VEVORISERTIB | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL4297188 | MIRANSERTIB | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4635254 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4795065 | Borussertib | IC50 | = | 56.0 | nM | 7.25 |