Assay Detail
Binding
CHEMBL5223244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Mca-AVLQSGFR-K(Dnp)K as substrate by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A review of the latest research on M<sup>pro</sup> targeting SARS-COV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.17 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.17 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 6.17 |
| CHEMBL3545157 | TIDEGLUSIB | 2.0 | 1 | 6.17 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 6.17 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.17 |
| CHEMBL406050 | PX-12 | 2.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3545157 | TIDEGLUSIB | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL406050 | PX-12 | IC50 | = | 670.0 | nM | 6.17 |