Assay Detail
Binding
CHEMBL5223256
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Inhibition of West Nile virus NS2B (1393 to 1440 residues)-NS3 (1476 to 1687 residues) protease expressed in Escherichia coli BL21 (DE3) codon plus cells using Pyr-RTKR-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by fluorescence spectrophotometric analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the protease of West Nile virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.98 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569561 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569561 | — | IC50 | = | 105.0 | nM | 6.98 |