Assay Detail
Functional
CHEMBL5223483
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Antiproliferative activity against mouse BaF3-LMNA-NTRK1-G595 mutant cells assessed as cell viability measured after 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.79 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282675 | — | — | 1 | 6.30 |
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | 5.60 |
| CHEMBL5266269 | — | — | 1 | 5.48 |
| CHEMBL5288589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282675 | — | IC50 | = | 495.3 | nM | 6.30 |
| CHEMBL3889654 | LAROTRECTINIB | IC50 | = | 2504.7 | nM | 5.60 |
| CHEMBL5266269 | — | IC50 | = | 3336.6 | nM | 5.48 |
| CHEMBL5288589 | — | IC50 | - | — | - |