Assay Detail
Functional
CHEMBL5223485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 expressing the green fluorescence protein infected in mouse RAW264.7 cells assessed as inhibition of bacterial growth pre-infected with cell followed by compound addition and measured after 5 days by Hoechst 33342 staining based analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.52 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 7.22 |
| CHEMBL5271330 | — | — | 1 | 7.00 |
| CHEMBL5289264 | — | — | 1 | 6.96 |
| CHEMBL5282383 | — | — | 1 | 6.96 |
| CHEMBL5283928 | — | — | 1 | 6.77 |
| CHEMBL5268713 | — | — | 1 | 6.72 |
| CHEMBL5267910 | — | — | 1 | 6.72 |
| CHEMBL5280742 | — | — | 1 | 6.70 |
| CHEMBL5272617 | — | — | 1 | 6.68 |
| CHEMBL5283107 | — | — | 1 | 6.68 |
| CHEMBL5289282 | — | — | 1 | 6.68 |
| CHEMBL5279170 | — | — | 1 | 6.64 |
| CHEMBL5276526 | — | — | 1 | 6.60 |
| CHEMBL5284665 | — | — | 1 | 6.57 |
| CHEMBL5274019 | — | — | 1 | 6.51 |
| CHEMBL5273568 | — | — | 1 | 6.48 |
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 6.46 |
| CHEMBL5290102 | — | — | 1 | 6.44 |
| CHEMBL5270444 | — | — | 1 | 6.43 |
| CHEMBL5288259 | — | — | 1 | 6.34 |
| CHEMBL5281280 | — | — | 1 | 6.33 |
| CHEMBL5273175 | — | — | 1 | 6.29 |
| CHEMBL5283080 | — | — | 1 | 6.16 |
| CHEMBL5268032 | — | — | 1 | 5.89 |
| CHEMBL5267127 | — | — | 1 | 5.68 |
| CHEMBL5290680 | — | — | 1 | 5.56 |
| CHEMBL5288054 | — | — | 1 | - |
| CHEMBL5272865 | — | — | 1 | - |
| CHEMBL5284586 | — | — | 1 | - |
| CHEMBL5281858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5271330 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5289264 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5282383 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5283928 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5268713 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5267910 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5280742 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5272617 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5283107 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5289282 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5279170 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5276526 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5284665 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5274019 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5273568 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL64 | ISONIAZID | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5290102 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5270444 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5288259 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5281280 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5273175 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5283080 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5268032 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5267127 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5290680 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL5288054 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5272865 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5284586 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5281858 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5276367 | — | IC50 | > | 20000.0 | nM | - |