Assay Detail

CHEMBL5223709

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Binding

Displacement of [3H]CHA from adenosine A1 receptor derived from rat brain membrane assessed as inhibition constant

ChEMBL ↗

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Target

Adenosine receptor A1 (CHEMBL318) ↗

Open DB target context

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Adenosine receptor A1 (CHEMBL318) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adenosine receptor A1

CHEMBL318

Anchored from Assay target.

Protein identity Adenosine receptor A1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Brain
Subcellular	Membrane
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Adenosine receptor A1 (CHEMBL318) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

The Medicinal Chemistry of Caffeine.

Faudone G, Arifi S, Merk D.
J Med Chem (2021) 64 : 7156 -7178
PubMed 34019396 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.34	9.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL183	1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX]	—	1	9.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL183	1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX]	Ki	=	0.46	nM	9.34