Assay Detail
Binding
CHEMBL5223946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human MDM2 assessed as inhibition constant
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.37 | 9.68 |
| Kd | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3657129 | — | — | 1 | 9.68 |
| CHEMBL5290323 | — | — | 1 | 9.05 |
| CHEMBL4289676 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3657129 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5290323 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4289676 | — | Kd | = | 600.0 | nM | 6.22 |