Assay Detail
ADMET
CHEMBL5224626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP17A1
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3696099 | — | — | 1 | 9.00 |
| CHEMBL5284599 | — | — | 1 | 8.70 |
| CHEMBL5286021 | — | — | 1 | 8.52 |
| CHEMBL5290743 | — | — | 1 | 8.52 |
| CHEMBL5265986 | — | — | 1 | 8.40 |
| CHEMBL5284859 | — | — | 1 | 8.40 |
| CHEMBL5280658 | — | — | 1 | 8.30 |
| CHEMBL5286147 | — | — | 1 | 8.30 |
| CHEMBL5290106 | — | — | 1 | 8.30 |
| CHEMBL5269382 | — | — | 1 | 8.30 |
| CHEMBL5284207 | — | — | 1 | 8.30 |
| CHEMBL5286511 | — | — | 1 | 8.22 |
| CHEMBL5266728 | — | — | 1 | 8.15 |
| CHEMBL5290740 | — | — | 1 | 8.10 |
| CHEMBL5269068 | — | — | 1 | 8.10 |
| CHEMBL5277196 | — | — | 1 | 8.05 |
| CHEMBL5274940 | — | — | 1 | 8.05 |
| CHEMBL5285321 | — | — | 1 | 8.00 |
| CHEMBL5282485 | — | — | 1 | 7.96 |
| CHEMBL5286288 | — | — | 1 | 7.96 |
| CHEMBL5290887 | — | — | 1 | 7.96 |
| CHEMBL5275088 | — | — | 1 | 7.85 |
| CHEMBL5267216 | — | — | 1 | 7.85 |
| CHEMBL5290029 | — | — | 1 | 7.80 |
| CHEMBL5289188 | — | — | 1 | 7.64 |
| CHEMBL5287403 | — | — | 1 | 7.62 |
| CHEMBL5265915 | — | — | 1 | 7.57 |
| CHEMBL3956116 | — | — | 1 | 7.39 |
| CHEMBL5275896 | — | — | 1 | 7.34 |
| CHEMBL3902750 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3696099 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5284599 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5290743 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5286021 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5265986 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5284859 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5284207 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5269382 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5290106 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5286147 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5280658 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5286511 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5266728 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5290740 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5269068 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5277196 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5274940 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5285321 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5290887 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5282485 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5286288 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5275088 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5267216 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5290029 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5289188 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5287403 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5265915 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3956116 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5275896 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3902750 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5267919 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5267699 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5276101 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5267526 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5276695 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5284019 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL5278006 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL5289901 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL5278719 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5287872 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5282733 | — | IC50 | > | 1000.0 | nM | - |