Assay Detail
ADMET
CHEMBL5224630
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Inhibition of CYP1A2 (unknown origin)
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.98 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3696099 | — | — | 1 | 7.55 |
| CHEMBL5284599 | — | — | 1 | 7.47 |
| CHEMBL3902750 | — | — | 1 | 7.24 |
| CHEMBL5286021 | — | — | 1 | 6.87 |
| CHEMBL5290740 | — | — | 1 | 6.85 |
| CHEMBL5280658 | — | — | 1 | 6.75 |
| CHEMBL5267526 | — | — | 1 | 6.67 |
| CHEMBL5285321 | — | — | 1 | 6.60 |
| CHEMBL5265915 | — | — | 1 | 6.55 |
| CHEMBL3956116 | — | — | 1 | 6.50 |
| CHEMBL5284207 | — | — | 1 | 6.49 |
| CHEMBL5286511 | — | — | 1 | 6.42 |
| CHEMBL5266728 | — | — | 1 | 6.25 |
| CHEMBL5267699 | — | — | 1 | 6.21 |
| CHEMBL5287403 | — | — | 1 | 6.18 |
| CHEMBL5289188 | — | — | 1 | 6.18 |
| CHEMBL5286288 | — | — | 1 | 6.14 |
| CHEMBL5290743 | — | — | 1 | 5.83 |
| CHEMBL5284019 | — | — | 1 | 5.67 |
| CHEMBL5287872 | — | — | 1 | 5.63 |
| CHEMBL5278006 | — | — | 1 | 5.56 |
| CHEMBL5275088 | — | — | 1 | 5.33 |
| CHEMBL5269068 | — | — | 1 | 5.33 |
| CHEMBL5278719 | — | — | 1 | 5.29 |
| CHEMBL5274940 | — | — | 1 | 5.28 |
| CHEMBL5276101 | — | — | 1 | 5.28 |
| CHEMBL5284859 | — | — | 1 | 5.06 |
| CHEMBL5275896 | — | — | 1 | 4.96 |
| CHEMBL5267919 | — | — | 1 | 4.95 |
| CHEMBL5277196 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3696099 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5284599 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3902750 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5286021 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5290740 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5280658 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5267526 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5285321 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5265915 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL3956116 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL5284207 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL5286511 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL5266728 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5267699 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL5289188 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL5287403 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL5286288 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL5290743 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5284019 | — | IC50 | = | 2142.0 | nM | 5.67 |
| CHEMBL5287872 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5278006 | — | IC50 | = | 2741.0 | nM | 5.56 |
| CHEMBL5269068 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL5275088 | — | IC50 | = | 4736.0 | nM | 5.33 |
| CHEMBL5278719 | — | IC50 | = | 5144.0 | nM | 5.29 |
| CHEMBL5274940 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5276101 | — | IC50 | = | 5283.0 | nM | 5.28 |
| CHEMBL5284859 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5275896 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL5267919 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL5277196 | — | IC50 | = | 15440.0 | nM | 4.81 |
| CHEMBL5269382 | — | IC50 | = | 16680.0 | nM | 4.78 |
| CHEMBL5290106 | — | IC50 | = | 26880.0 | nM | 4.57 |
| CHEMBL5290029 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5265986 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5282733 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5282485 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5267216 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5286147 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5276695 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5289901 | — | IC50 | > | 40000.0 | nM | - |