Assay Detail
Functional
CHEMBL5224778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring EGFR del19/T790M double mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel macrocyclic derivatives bearing aniline pyrimidine scaffolds as EGFR-TKIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.03 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.48 |
| CHEMBL5290583 | — | — | 1 | 7.46 |
| CHEMBL5269317 | — | — | 1 | 7.29 |
| CHEMBL5273197 | — | — | 1 | 7.20 |
| CHEMBL5289304 | — | — | 1 | 6.83 |
| CHEMBL5287438 | — | — | 1 | 6.67 |
| CHEMBL5286636 | — | — | 1 | 6.67 |
| CHEMBL5274514 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5290583 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5269317 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5273197 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5289304 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL5287438 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL5286636 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL5274514 | — | IC50 | = | 218.0 | nM | 6.66 |