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Assay Detail

CHEMBL5225067

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human PD-1/PDL1 protein-protein interaction by HTRF assay
ChEMBL ↗
97
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction.
Sasmal P, Kumar Babasahib S, Prashantha Kumar BR, Manjunathaiah Raghavendra N.
Bioorg Med Chem (2022) 73 : 117001 -117001
PubMed 36126447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 97 7.33 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4089730 — — 1 7.75
CHEMBL5266711 — — 1 7.66
CHEMBL5315609 — — 1 7.37
CHEMBL5271819 — — 1 7.25
CHEMBL5279835 — — 1 7.10
CHEMBL4099869 — — 1 6.84
CHEMBL5285577 — — 1 -
CHEMBL5287322 — — 1 -
CHEMBL5272773 — — 1 -
CHEMBL4592968 — — 1 -
CHEMBL5287896 — — 1 -
CHEMBL5284076 — — 1 -
CHEMBL5288158 — — 1 -
CHEMBL5272092 — — 1 -
CHEMBL5277379 — — 1 -
CHEMBL5275793 — — 1 -
CHEMBL5275699 — — 1 -
CHEMBL5291437 — — 1 -
CHEMBL5265868 — — 1 -
CHEMBL5289522 — — 1 -
CHEMBL5282766 — — 1 -
CHEMBL4753604 — — 1 -
CHEMBL5281924 — — 1 -
CHEMBL5287199 — — 1 -
CHEMBL5272322 — — 1 -
CHEMBL5275302 — — 1 -
CHEMBL5275469 — — 1 -
CHEMBL5267754 — — 1 -
CHEMBL4637826 — — 1 -
CHEMBL5268649 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4089730 — IC50 = 18.0 nM 7.75
CHEMBL5266711 — IC50 = 22.0 nM 7.66
CHEMBL5315609 — IC50 = 43.0 nM 7.37
CHEMBL5271819 — IC50 = 56.58 nM 7.25
CHEMBL5279835 — IC50 = 80.0 nM 7.10
CHEMBL4099869 — IC50 = 146.0 nM 6.84
CHEMBL5265826 — IC50 <= 100.0 nM -
CHEMBL5291437 — IC50 <= 100.0 nM -
CHEMBL5268728 — IC50 <= 100.0 nM -
CHEMBL5279513 — IC50 <= 100.0 nM -
CHEMBL5266819 — IC50 <= 100.0 nM -
CHEMBL5270993 — IC50 <= 100.0 nM -
CHEMBL5272481 — IC50 <= 100.0 nM -
CHEMBL5279917 — IC50 <= 100.0 nM -
CHEMBL5287342 — IC50 <= 100.0 nM -
CHEMBL5287322 — IC50 <= 100.0 nM -
CHEMBL5278095 — IC50 <= 100.0 nM -
CHEMBL5278245 — IC50 <= 100.0 nM -
CHEMBL5272572 — IC50 <= 100.0 nM -
CHEMBL4636289 — IC50 <= 100.0 nM -
CHEMBL5272377 — IC50 <= 100.0 nM -
CHEMBL5286443 — IC50 <= 100.0 nM -
CHEMBL5288963 — IC50 <= 100.0 nM -
CHEMBL4460496 — IC50 <= 100.0 nM -
CHEMBL5279766 — IC50 <= 100.0 nM -
CHEMBL5287692 — IC50 <= 100.0 nM -
CHEMBL5277934 — IC50 <= 100.0 nM -
CHEMBL5288737 — IC50 <= 100.0 nM -
CHEMBL5289522 — IC50 <= 10.0 nM -
CHEMBL5268649 — IC50 <= 10.0 nM -
CHEMBL4637826 — IC50 <= 10.0 nM -
CHEMBL5267754 — IC50 <= 10.0 nM -
CHEMBL5275469 — IC50 <= 10.0 nM -
CHEMBL5275302 — IC50 <= 10.0 nM -
CHEMBL5272322 — IC50 <= 10.0 nM -
CHEMBL5287199 — IC50 <= 10.0 nM -
CHEMBL5281924 — IC50 <= 10.0 nM -
CHEMBL4753604 — IC50 <= 10.0 nM -
CHEMBL5282766 — IC50 <= 10.0 nM -
CHEMBL5275699 — IC50 <= 10.0 nM -
CHEMBL5265868 — IC50 <= 10.0 nM -
CHEMBL5285577 — IC50 <= 10.0 nM -
CHEMBL5272773 — IC50 <= 10.0 nM -
CHEMBL4592968 — IC50 <= 10.0 nM -
CHEMBL5287896 — IC50 <= 10.0 nM -
CHEMBL5284076 — IC50 <= 10.0 nM -
CHEMBL5288158 — IC50 <= 10.0 nM -
CHEMBL5272092 — IC50 <= 10.0 nM -
CHEMBL5277379 — IC50 <= 10.0 nM -
CHEMBL5275793 — IC50 <= 10.0 nM -