Assay Detail
Binding
CHEMBL5225068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PD-1/PDL1 protein-protein interaction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.75 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099869 | — | — | 1 | 7.75 |
| CHEMBL4089730 | — | — | 1 | 7.75 |
| CHEMBL5266711 | — | — | 1 | 7.75 |
| CHEMBL5315609 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099869 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4089730 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5266711 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5315609 | — | IC50 | = | 18.0 | nM | 7.75 |