Assay Detail
Binding
CHEMBL5225132
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Binding affinity to human sigma 2 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.38 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.75 |
| CHEMBL50112 | — | — | 1 | 7.60 |
| CHEMBL190883 | — | — | 1 | 6.77 |
| CHEMBL4088272 | — | — | 1 | 5.86 |
| CHEMBL5270434 | — | — | 1 | 5.81 |
| CHEMBL305881 | — | — | 1 | 4.49 |
| CHEMBL2170062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL50112 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL190883 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4088272 | — | Ki | = | 1377.0 | nM | 5.86 |
| CHEMBL5270434 | — | Ki | = | 1542.0 | nM | 5.81 |
| CHEMBL305881 | — | Ki | = | 32100.0 | nM | 4.49 |
| CHEMBL2170062 | — | Ki | > | 1000.0 | nM | - |