Assay Detail
Binding
CHEMBL5225141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma 2 receptor expressed in rat liver
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.50 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5291247 | — | — | 1 | 7.85 |
| CHEMBL5279451 | — | — | 1 | 7.58 |
| CHEMBL3104857 | — | — | 1 | 7.42 |
| CHEMBL3104856 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5291247 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5279451 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3104857 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3104856 | — | Ki | = | 73.0 | nM | 7.14 |