Assay Detail
Functional
CHEMBL5225527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.45 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271605 | — | — | 1 | 6.88 |
| CHEMBL5287072 | — | — | 1 | 6.72 |
| CHEMBL5268304 | — | — | 1 | 6.64 |
| CHEMBL5288494 | — | — | 1 | 6.59 |
| CHEMBL5276264 | — | — | 1 | 6.44 |
| CHEMBL5273130 | — | — | 1 | 6.36 |
| CHEMBL5282636 | — | — | 1 | 6.19 |
| CHEMBL5265945 | — | — | 1 | 6.16 |
| CHEMBL5289344 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271605 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5287072 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL5268304 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5288494 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5276264 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL5273130 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL5282636 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL5265945 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL5289344 | — | IC50 | = | 881.0 | nM | 6.05 |