Assay Detail
Functional
CHEMBL5225529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.62 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271605 | — | — | 1 | 7.40 |
| CHEMBL5287072 | — | — | 1 | 6.59 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 6.42 |
| CHEMBL5273130 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271605 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5287072 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL5273130 | — | IC50 | = | 863.0 | nM | 6.06 |