Assay Detail
Functional
CHEMBL5225530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring FLT3-D835F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.37 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 6.92 |
| CHEMBL5271605 | — | — | 1 | 6.88 |
| CHEMBL5287072 | — | — | 1 | 6.16 |
| CHEMBL5273130 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5271605 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL5287072 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL5273130 | — | IC50 | = | 3102.0 | nM | 5.51 |