Assay Detail
Functional
CHEMBL5225726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-375 cells incubated for 4 days by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Coumarin-Based MEK1/2 PROTAC Effective in Human Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.64 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092195 | — | — | 1 | 5.72 |
| CHEMBL5280597 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092195 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5280597 | — | IC50 | = | 2800.0 | nM | 5.55 |