Assay Detail
Functional
CHEMBL5225880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta level incubated for 48 hrs by ELISA assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.07 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270204 | — | — | 1 | 6.01 |
| CHEMBL5290776 | — | — | 1 | 5.99 |
| CHEMBL5265923 | — | — | 1 | 5.95 |
| CHEMBL5275936 | — | — | 1 | 5.91 |
| CHEMBL5277425 | — | — | 1 | 5.81 |
| CHEMBL5266874 | — | — | 1 | 5.57 |
| CHEMBL5273423 | — | — | 1 | 5.45 |
| CHEMBL5277599 | — | — | 1 | 5.04 |
| CHEMBL5265765 | — | — | 1 | 5.03 |
| CHEMBL5272454 | — | — | 1 | 5.01 |
| CHEMBL5289904 | — | — | 1 | 4.67 |
| CHEMBL5288315 | — | — | 1 | 4.56 |
| CHEMBL5281084 | — | — | 1 | 4.55 |
| CHEMBL574391 | — | — | 1 | 4.53 |
| CHEMBL5281509 | — | — | 1 | 4.44 |
| CHEMBL5283824 | — | — | 1 | 4.41 |
| CHEMBL5269578 | — | — | 1 | 4.39 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270204 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5290776 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5265923 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5275936 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5277425 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5266874 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL5273423 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL5277599 | — | IC50 | = | 9170.0 | nM | 5.04 |
| CHEMBL5265765 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL5272454 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5289904 | — | IC50 | = | 21160.0 | nM | 4.67 |
| CHEMBL5288315 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL5281084 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL574391 | — | IC50 | = | 29470.0 | nM | 4.53 |
| CHEMBL5281509 | — | IC50 | = | 36570.0 | nM | 4.44 |
| CHEMBL5283824 | — | IC50 | = | 39280.0 | nM | 4.41 |
| CHEMBL5269578 | — | IC50 | = | 40450.0 | nM | 4.39 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 96630.0 | nM | 4.01 |