Assay Detail
Binding
CHEMBL5225957
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Inhibition of SARS-CoV-2 RdRp using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by Alphascreen microplate reader analysis
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.19 | 5.70 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279597 | — | — | 1 | 5.70 |
| CHEMBL5286682 | — | — | 1 | 5.47 |
| CHEMBL5278945 | — | — | 1 | 5.39 |
| CHEMBL5280903 | — | — | 1 | 5.37 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.34 |
| CHEMBL3326854 | — | — | 1 | 5.28 |
| CHEMBL5272459 | — | — | 1 | 5.25 |
| CHEMBL5284676 | — | — | 1 | 5.24 |
| CHEMBL594248 | — | — | 1 | 5.22 |
| CHEMBL5284680 | — | — | 1 | 5.21 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.16 |
| CHEMBL228623 | — | — | 1 | 5.16 |
| CHEMBL5279962 | — | — | 1 | 5.15 |
| CHEMBL5281399 | — | — | 1 | 5.07 |
| CHEMBL5271510 | — | — | 1 | 5.06 |
| CHEMBL5279136 | — | — | 1 | 4.80 |
| CHEMBL5281483 | — | — | 1 | 4.36 |
| CHEMBL5291220 | — | — | 1 | - |
| CHEMBL5281756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279597 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5286682 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5278945 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5280903 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3326854 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5272459 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5284676 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL594248 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5284680 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL50 | QUERCETIN | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL228623 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5279962 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5281399 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5271510 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5279136 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5281483 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL5291220 | — | Inhibition | - | % | - | |
| CHEMBL5281756 | — | IC50 | > | 100000.0 | nM | - |