Assay Detail
Binding
CHEMBL5225968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GCS in human fibroblast
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.47 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297611 | VENGLUSTAT | 3.0 | 1 | 7.92 |
| CHEMBL5273314 | — | — | 1 | 7.68 |
| CHEMBL5288633 | — | — | 1 | 7.50 |
| CHEMBL5275403 | — | — | 1 | 7.50 |
| CHEMBL5278676 | — | — | 1 | 7.50 |
| CHEMBL5286066 | — | — | 1 | 7.50 |
| CHEMBL5286071 | — | — | 1 | 7.48 |
| CHEMBL5272946 | — | — | 1 | 7.47 |
| CHEMBL5278405 | — | — | 1 | 7.46 |
| CHEMBL5278640 | — | — | 1 | 7.43 |
| CHEMBL5270537 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297611 | VENGLUSTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5273314 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5288633 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5275403 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5278676 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5286066 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5286071 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5272946 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5278405 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5278640 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5270537 | — | IC50 | = | 180.0 | nM | 6.75 |