Assay Detail
Binding
CHEMBL5225977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GCS in mouse fibroblast
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Fibroblast |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.73 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275403 | — | — | 1 | 7.77 |
| CHEMBL5272946 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275403 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5272946 | — | IC50 | = | 21.0 | nM | 7.68 |