Assay Detail
Binding
CHEMBL5226007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GCS in human iPSC derived neurons assessed as reduction in brain GlcCer levels
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Neuron |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 8.77 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275403 | — | — | 2 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275403 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5275403 | — | Inhibition | - | % | - |