Assay Detail
Binding
CHEMBL5226427
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Inhibition of HDAC10 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.70 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.51 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.06 |
| CHEMBL5280773 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5280773 | — | IC50 | = | 4610.0 | nM | 5.34 |