Assay Detail
Binding
CHEMBL5226482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis DXR in presence of NADPH by spectrophotometric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL5630) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Non-hydroxamate inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): A critical review and future perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.95 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 7.10 |
| CHEMBL205338 | FR-900098 | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL205338 | FR-900098 | IC50 | = | 160.0 | nM | 6.80 |