Assay Detail
Binding
CHEMBL5226510
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Agonist activity at TLR2/TLR1 in mouse Macrophage cell line
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Macrophage cell line |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 76 | 6.91 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279981 | — | — | 1 | 8.96 |
| CHEMBL5265998 | — | — | 1 | 8.92 |
| CHEMBL4472879 | — | — | 1 | 8.89 |
| CHEMBL5267649 | — | — | 1 | 8.68 |
| CHEMBL5283414 | — | — | 1 | 8.59 |
| CHEMBL5275357 | — | — | 1 | 8.40 |
| CHEMBL5276021 | — | — | 1 | 8.00 |
| CHEMBL5266783 | — | — | 1 | 7.52 |
| CHEMBL5269670 | — | — | 1 | 7.22 |
| CHEMBL5282814 | — | — | 1 | 7.10 |
| CHEMBL5284136 | — | — | 1 | 6.89 |
| CHEMBL5270396 | — | — | 1 | 6.85 |
| CHEMBL5290188 | — | — | 1 | 6.60 |
| CHEMBL5265874 | — | — | 1 | 6.57 |
| CHEMBL5268745 | — | — | 1 | 6.44 |
| CHEMBL5285744 | — | — | 1 | 6.44 |
| CHEMBL5290872 | — | — | 1 | 6.42 |
| CHEMBL5281226 | — | — | 1 | 6.27 |
| CHEMBL5279150 | — | — | 1 | 6.21 |
| CHEMBL5275812 | — | — | 1 | 6.19 |
| CHEMBL5273912 | — | — | 1 | 6.19 |
| CHEMBL5288666 | — | — | 1 | 6.15 |
| CHEMBL5268164 | — | — | 1 | 6.12 |
| CHEMBL5284270 | — | — | 1 | 6.00 |
| CHEMBL5267977 | — | — | 1 | 6.00 |
| CHEMBL5290373 | — | — | 1 | 5.96 |
| CHEMBL5289224 | — | — | 1 | 5.96 |
| CHEMBL5275065 | — | — | 1 | 5.64 |
| CHEMBL5276334 | — | — | 1 | 5.30 |
| CHEMBL5286009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279981 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5265998 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4472879 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5267649 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5283414 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5275357 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5276021 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5266783 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5269670 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5282814 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5284136 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5270396 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5290188 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5265874 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5285744 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5268745 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5290872 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5281226 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5279150 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5275812 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5273912 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5288666 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5268164 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5284270 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5267977 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5290373 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5289224 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5275065 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5276334 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5274358 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5288689 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5276674 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5285656 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5286904 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5287249 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5277385 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5285211 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5277275 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5270695 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5275663 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5285504 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5277072 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5280156 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5280705 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5274222 | — | EC50 | > | 5.0 | nM | - |
| CHEMBL5284284 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5269956 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5284401 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5266365 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5286009 | — | EC50 | > | 5000.0 | nM | - |