Assay Detail
Binding
CHEMBL5226654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate incubated for 20 mins by DTNB-reagent based Ellman's method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.04 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435044 | — | — | 1 | 6.82 |
| CHEMBL5271210 | — | — | 1 | 5.82 |
| CHEMBL5275356 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435044 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5271210 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5275356 | — | IC50 | = | 3231.0 | nM | 5.49 |